发明名称 NOVEL ANTI-VIRAL COMPOUNDS AND PROCESSES FOR PRODUCTION OF ANTI-VIRAL COMPOUNDS
摘要 <p>A process for recovering zidovudine or a derivative thereof from a mixture of chemicals comprising zidovudine or a derivative thereof. The process comprises the steps of: (i) reacting zidovudine or a derivative thereof in the mixture with a reagent selected from the group consisting of guanidine, a combination of a base and a guanidine salt, and mixtures thereof, to form a precipitated salt; (ii) acidifying the salt to a pH of less than about 9 to produce substantially pure zidovudine or a derivative thereof; and (iii) recovering the substantially pure zidovudine or a derivative thereof. Zidovudine, also known as AZT, and its derivatives have known anti-viral properties which render them useful in the treatment of, inter alia, AIDS. An aspect of the invention also relates to a novel compound having formula (I): wherein X is selected from the group comprising hydrogen, methyl, trifluoromethyl, propenyl, fluoro, chloro, bromo and iodo. A process for producing the compound of formula (I) is also provided.</p>
申请公布号 WO1993000351(A1) 申请公布日期 1993.01.07
申请号 CA1992000269 申请日期 1992.06.22
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