| 发明名称 |
CALPAIN-INHIBITING PEPTIDE ANALOGS OF THE KININOGEN HEAVY CHAIN |
| 摘要 |
2111870 9300105 PCTABS00019 Synthetic peptide analogs of human kininogen are provided which are conformationally restricted by means of intramolecular bonding. The peptides mimic the biological activity of human kininogen by inhibiting the activity of the biologically significant protease, calpain. The peptides are designed by means of an equilibrium conformational model of the kininogen heavy chain.
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| 申请公布号 |
CA2111870(A1) |
申请公布日期 |
1993.01.07 |
| 申请号 |
CA19922111870 |
申请日期 |
1992.06.15 |
| 申请人 |
TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
COLMAN, ROBERT W.;BRADFORD, HARLAN N.;JAMESON, BRADFORD A. |
| 分类号 |
A61K38/55;A61K38/00;A61P7/02;C07K1/00;C07K1/113;C07K7/06;C07K7/08;C07K14/00;C07K14/81;(IPC1-7):C07K7/04;A61K38/04;A61K38/17;C07K14/47 |
主分类号 |
A61K38/55 |
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