发明名称 DECAHYDROQUINOLINE DERIVATIVES, METHOD FOR THEIR PREPARATION AND INTERMEDIATES THEREOF, THEIR USE AS MEDICAMENTS AND THEIR PHARMACEUTICAL COMPOSITIONS
摘要 <p>A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms of a decahydroquinoline of the formula <IMAGE> I wherein R1 is alkyl of 1 to 5 carbon atoms, R2 is selected from the group consisting of hydrogen and akyl of 1 to 5 carbon atoms, A is selected from the group consisting of -(CH2)n-, -CH2O- and alkylene substituted with alkyl having a total of 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, optionally substituted naphthyl, optionally substituted indenyl, optionally substituted heteromonocycle of 5 to 6 members and optionally substituted heterobicycle with the proviso that when Z is o-alkoxy-phenyl, A is not -(CH2)n- in which n is O, and their non-toxic, pharmaceutically acceptable acid addition salts and their quaternary ammonium salts and intermediates having analgesic, diuretic, hypotensive, anti-arrithmic and anti-cerebral-ischaemic properties.</p>
申请公布号 GR3002264(T3) 申请公布日期 1992.12.30
申请号 GR19900401171T 申请日期 1991.07.05
申请人 ROUSSEL-UCLAF 发明人 CLEMENCE, FRANCOIS;LE MARTRET, ODILE;DELEVALLEE, FRANCOISE;FORTIN, MICHEL
分类号 A61K31/47;A61P7/06;A61P7/10;A61P9/06;A61P9/12;A61P25/04;C07D215/40;C07D401/12;C07D409/12;(IPC1-7):C07D215/40 主分类号 A61K31/47
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