摘要 |
<p>11 beta -substituted steroids of the formula <IMAGE> wherein A and B together represent a second bond between the 6-position and 7-position carbon atoms, or, respectively, are each H; X is O, two H atoms or hydroximino; Z is the residue of a pentagonal or hexagonal ring which is optionally substituted and optionally saturated; R1 is vinyl, C3-7-cyclo-1-alkenyl, phenyl, naphthyl or 5- or 6-membered heterocyclic aromatic having at least one N, O or S atom, each being unsubstituted or substituted by 1-3 halogen atoms, 1-3 C1-4-alkyl, C1-4-alkoxy, C1-4-acyl, C2-10-alkenyl, C1-4-acyloxy, phenyl, nitro, hydroxy, carboxy, cyanide, COOR4 or amino optionally substituted by 1-2 C1-4-alkyl; R2 is methyl or ethyl, R3 is H, Cl or methyl; and R4 is C1-4-alkyl optionally substituted by phenyl which itself is optionally substituted by C1-4-alkyl, C1-4-alkoxy, halogen or phenyl have valuable pharmacological properties.</p> |
申请人 |
SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN |
发明人 |
OTTOW, ECKHARD, DR.;WIECHERT, RUDOLF, PROF. DR.;NEEF, GUENTER, DR.;BARDENHAGEN, JUERGEN, DR.;BEIER, SYBILLE, DR.;ELGER, WALTER, DR.;HENDERSON, DAVID, DR. |