| 摘要 |
A family of compounds effective in inhibiting replication of a human retrovirus is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of the formula: <CHEM> in which R1 and R2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group. Another family of effective compounds is comprised of compounds of the formula: <CHEM> wherein at least one of R1 and R3 is either a) a branched hydroxyalkyl group of the formula <CHEM> in which R<4> stands for an alkyl group with 1 to 3 carbon atoms and n stands for a whole number from 2 to 5, the other R<1> or R<3> group that may optionally be present stands for a hydrogen atom or on aliphatic hydrocarbon group R<5> with up to 6 carbon atoms, whose carbon chain may be interrupted by up to 2 oxygen atoms or may be substituted with a hydroxy or oxo group, or b) an oxoallyl group of the formula <CHEM> wherein R<6> is C1-C6 and p is 2, 3 or 4, the remaining R<1> or R<3> being as defined above, and R<2> is an alkyl group C1-C4. The inhibition of replication of human retroviruses is indicated in humans infected by human immunodeficiency virus (HIV) or susceptible to HIV infection. v |
