| 摘要 |
The present invention relates to a class of compounds represented by the formula: <CHEM> or a pharmaceutically acceptable salt thereof, wherein W is the radical OR1 wherein R1 is hydrido, alkyl, phenyl, phenylalkyl which may be further substituted; or W is the amino radical of the formula NHOH; R2 is hydrido, alkyl, alkenyl, cycloalkyl, cycloalkenyl which may be further substituted; or R2 is phenyl, phenylalkyl, naphthyl, naphthylalkyl which may be further substituted; or R2 is a heteromonocyclic ring structure having 5 or 6 ring carbon atoms wherein 1 or 2 of the ring carbon atoms are replaced by nitrogen, oxygen or sulfur and wherein the ring is selected from saturated, partially unsaturated, and fully unsaturated rings or a fused bicyclic ring structure having 10 to 12 ring carbon atoms wherein 1 to 3 of the ring carbon atoms may be replaced by nitrogen, oxygen or sulfur and each ring may independently be saturated, partially unsaturated or fully unsaturated which may be further stituted; R3 and R4 are each independently selected from hydrido, alkyl having 1 to 6 carbon atoms, hydroxy and halo; R5 and R6 are each independently selected from hydrido, alkyl having 1 to 6 carbon atoms, hydroxy, halo and alkoxy having 1 to 6 carbon atoms; and Y is alkyl having 1 to 6 carbon atoms, alkenyl having 2 to 6 carbon atoms, alkynyl having 2 to 6 carbon atoms or carbonylalkyl which may be further substituted. Such compounds and compositions thereof have usefulness as inhibitors of platelet aggregation. |
