Dipeptide hydroxy ethylene isostere synthesis and intermediates therefor

摘要

PCT No. PCT/US89/02452 Sec. 371 Date Dec. 11, 1990 Sec. 102(e) Date Dec. 11, 1990 PCT Filed Jun. 8, 1989.The present invention provides processes and intermediates for one preparation of the hydroxy ethylene isostere dipeptide of leu-val which is itself useful in the preparation of renin inhibitory peptides. The process employs certain novel oxazolidenes.