| 发明名称 |
CLIMOTRIPSINE-TYPE PROTEASES AND INHIBITORS |
| 摘要 |
Methods are disclosed for the detection of proteases indicative of Alzheimer's disease which are capable of cleaving beta -amyloid precursor protein between methionine and aspartic acid residues. Inhibitors and substrates for these enzymes are also described which are used in the preparation of agents for the treatment of the disease. <IMAGE> |
| 申请公布号 |
HU9202842(D0) |
申请公布日期 |
1992.12.28 |
| 申请号 |
HU19920002842 |
申请日期 |
1991.03.04 |
| 申请人 |
CEPHALON INC.,US |
发明人 |
SIMAN,ROBERT,US;NELSON,ROBERT B.,US;KAUER,JAMES C.,SU;POTTER,HUNTINGTON,US |
| 分类号 |
A61K38/55;A61K38/00;A61P25/28;C07C237/22;C07C279/14;C07K1/22;C07K5/02;C07K5/06;C07K5/08;C07K5/083;C07K5/087;C07K5/093;C07K5/097;C07K5/10;C07K5/107;C07K5/11;C07K5/113;C07K7/02;C07K7/06;C07K7/08;C12N9/00;C12N9/50;C12N9/64;C12N9/76;C12N9/99;C12Q1/37 |
主分类号 |
A61K38/55 |
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