| 发明名称 |
VERFAHREN ZUR HERSTELLUNG VON ALPHA-(1-METHYLETHYL)-3,4-DIMETHOXYBENZENEACETONITRIL. |
| 摘要 |
New process for the synthesis of the alpha -(1-methylethyl)-3,4-dimethoxyacetonitrile of formula <CHEM> intermediate in the synthesis of the drug internationally known as verapamil. The process starts from the isobutyryl-3,4-dimethoxybenzene of formula <CHEM> which, by means of the Darzens condensation, gives an epoxyester which, by alkaline hydrolysis and subsequent decarboxylation, gives the alpha -(1-methylethyl)-3,4-dimethoxybenzeneacetaldehyde. This product is reacted with hydroxylamine so obtaining the corresponding oxime that, by dehydratation, gives the nitrile of formula I. |
| 申请公布号 |
DE3875996(D1) |
申请公布日期 |
1992.12.24 |
| 申请号 |
DE19883875996 |
申请日期 |
1988.03.21 |
| 申请人 |
ALFA CHEMICALS ITALIANA S.R.L., BOLOGNA, IT |
发明人 |
CANNATA, VINCENZO, PONTECCHIO MARCONI (BOLOGNA), IT;TAMERLANI, GIANCARLO, I-40144 PONTECCHIO MARCONI (BOLOGNA), IT;ZAGNONI, GARZIANO, I-40038 VERGATO(BOLOGNA), IT |
| 分类号 |
C07D301/02;C07B61/00;C07C45/00;C07C45/58;C07C47/277;C07C67/00;C07C239/00;C07C249/08;C07C251/36;C07C251/40;C07C253/00;C07C255/37;C07C255/53;C07D303/48 |
主分类号 |
C07D301/02 |
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