| 摘要 |
2111214 9222317 PCTABS00018 A C-terminal substituted peptide or protein of formula (I), wherein X is a biologically active amphiphilic ion channel-forming peptide or protein. T is selected from the group consisting of: (a) O-R, wherein R is a substituted or unsubstituted aliphatic, aromatic or aralkyl group having from 1 to 10 carbon atoms; (b) NH-NH2; (c) NH-OH; and (d) .alpha., wherein R' and R" are hydrogen or selected from the class consisting of group (i) and group (ii), wherein group (i) is a hydroxy-substituted aliphatic, aromatic or aralkyl group having no more than 10 carbon atoms, and group (ii) is an amino-substituted aliphatic, aromatic, aralkyl, or alkylaromatic group, preferably having no more than 10 carbon atoms, and at least one of R' and R" is group (i) or group (ii).
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