摘要 |
Described is a process for the preparation of compositions of matter containing octalactones defined according to the structure: which includes the stereoisomers having the structures: I and I by means of the sequential steps of (i) fermentation of caprylic acid or the ethyl ester of caprylic acid defined according to the generic structure: OR wherein R is hydrogen or ethyl using a microorganism selected from the group consisting of: Mortierella isabellina, ATCC 44583; Mortierella isabellina, ATCC 38063; Syncephalastrum racemosum, NRRL A-5889; Mortierella isabellina, IFO 7884; Mortierella ramanniana var. angulispora, IFO 8187; Mortierella isabellina, CBS 221.29 Mortierella isabellina, IFO 7873; Mortierella ramanniana var. ramanniana, CBS 112.08; Mortierella ramanniana var. ramanniana, CBS 478 63; Choanephora cucurbitarum, NRRL 2744; Mortierella isabellina, IFO 8183; Mortierella isabellina, IFO 8309; Mortierella nana, IFO 8794; Mortierella isabellina, IFO 7824; and Mortierella vinacea, IFO 6738 whereby a gamma hydroxy octanoic acid defined according to the structure: OH is formed; and (ii) lactonization of the resulting gamma hydroxy octanoic acid by means of simultaneous acidification and heating according to the reaction sequence: and
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