| 摘要 |
New thioester and ester, amide and ketone isostere analogs of oleoyl coenzyme A, useful as antiatherosclerotic agents, are provided. The compounds have the formula: <IMAGE> wherein A is selected from the group consisting of <IMAGE> Y is selected from the group consisting of -S-, -O-, -NH- and (-CH2-)n wherein n=1 to 4; and Z is selected from the group consisting of alkyl (C1-C6), <IMAGE> wherein R=Hydrogen, C1-C4 alkyl or C1-C4 acyl, and <IMAGE>
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