发明名称 |
Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method |
摘要 |
Injectable aqueous compositions comprising folic acid and leucovorin and their salts, optionally including benzyl alcohol, sodium chloride and agents for adjusting pH are stabilized and buffered in the range of 6 to 10 by adding a combination of tromethamine and monothioglycerol. Such compositions remain stable for prolonged periods even when exposed to sunlight.
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申请公布号 |
US5173488(A) |
申请公布日期 |
1992.12.22 |
申请号 |
US19910696335 |
申请日期 |
1991.05.01 |
申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
HAEGER, BRUCE E. |
分类号 |
A61K9/00;A61K31/505;A61K47/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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