| 摘要 |
The present application relates to lipophilic conjugates of pharmaceutical compounds in admixture with a pharmaceutical vehicle not soluble in an aqueous solvent, such as a silicone oil useful as a sustained released pharmaceutical composition and methods for the treatment of medical disorders by administering an effective amount of such a sustained release pharmaceutical composition. In this invention a wide variety of pharmaceutical compounds are conjugated with the carrier and placed in admixture with a silicone oil. Acceptable compounds for conjugation with the carrier in this release delivery system include, for example, steroids (e.g., dexamethasone, prednisolone and related compounds), anti-neoplastic agents and/or ophthalmic agents (5-Fluorouracil, adriamycin and related compounds), anti-viral agents (ganciclovir, trifluorothymidine and related compounds), nonsteroidal anti-inflammatory agents (flurbiprofen, indomethacin and related compounds), anti-mitotic drugs (colchicine taxol and related compounds), drugs that act on actin polymerization (phalloidin, cytochlasin B and related compounds). Suitable lipophilic carrier molecules include long branched or unbranched alkyl chains. These chains may be saturated or unsaturated and may contain heteroatoms. Silicone chains may also be used. |
