发明名称 |
OLIGONUCLEOTIDE ANALOGS CONTAINING THIOFORMACETAL LINKAGES |
摘要 |
Oligonucleotide analogs wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by an formacetal/ketal type linkage are resistant to nucleases and do not need to exhibit the diastereomerism characteristic of many other oligonucleotide analogs, and thus are capable of strong hybridization to target RNA or DNA. These oligonucleotide analogs are useful in therapies which modulate gene expression using "antisense" or other specifically binding oligomers. |
申请公布号 |
AU1911392(A) |
申请公布日期 |
1992.12.21 |
申请号 |
AU19920019113 |
申请日期 |
1992.04.24 |
申请人 |
GILEAD SCIENCES, INC. |
发明人 |
MARK MATTEUCCI;BOB JONES;KUEI-YING LIN |
分类号 |
C07H19/06;C07H19/16;C07H21/00 |
主分类号 |
C07H19/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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