| 摘要 |
A process for producing an alpha -alkoxy acetic acids and salts thereof which comprises reacting an alcohol of the formula <CHEM> wherein R<1>, R<2> and R<3> can be hydrogen, alkyl, alkoxy, halo, phenyl, substituted phenyl, or hydroxy; A can be S, O or -CH2-; and Alk is straight or branched chain alkylene, with a base in an aprotic solvent, then reacting the resulting alkoxide with a monohaloacetic acid ester to give an alkoxyacetate followed by reaction of the alkoxyacetate with a hydrogen halide, organic acid or Lewis acid in nitromethane to give the corresponding alpha -alkoxyacetic acid which then may be recovered or may optionally be converted to the corresponding salt by contacting the alpha -alkoxyacetic acid with a base. |
