摘要 |
<p>2 alpha -Methyl-2 beta -(1,2,3-triazol-1-yl)methylpenam-3 alpha -carboxylic acid derivatives are prepared by reacting a penicillanic acid sulfoxide derivative of the formula <CHEM> wherein R is a penicillin carboxyl protecting group, and R1 is hydrogen or halogen, R2 is hydrogen, lower alkyl or the like with a triazole derivative of the formula <CHEM> wherein R3 and R4 are hydrogen, trialkylsilyl, lower alkyl, lower alkoxy or the like and R5 is hydrogen or silyl substituted with 3 groups selected from the class consisting of lower alkyl, benzyl and phenyl in a solvent.</p> |
申请人 |
OTSUKA KAGAKU K.K., OSAKA, JP;TAIHO PHARMACEUTICAL CO., LTD., TOKIO/TOKYO, JP |
发明人 |
TORII, SIGERU, AKAIWA-GUN, OKAYAMA-KEN, JP;TANAKA, HIDEO;TANAKA, MOTOAKI, OKAYAMA-SHI, OKAYAMA-KEN, JP;YAMADA, SHOZO, HONJYO-SHI, SAITAMA-KEN, JP;NAKAI, AKIRA, OKAYAMA-SHI, OKAYAMA-KEN, JP |