| 摘要 |
<p>A process for the preparation of a compound of general formula <CHEM> wherein X represents a cyano group, a group -COOH or a salt, ester or amido derivative thereof, R<1> represents a hydrogen atom or an optionally substituted alkyl group, R<2> represents an optionally substituted alkyl or phenyl group, Z represents an alkyl group or a halogen atom and n represents 0, 1, 2, 3 or 4, the process comprising reacting a compound of general formula <CHEM> with a first reactant capable of both dehydrating the amide group of said compound of general formula IV, to form a group X wherein X represents a cyano group, and reacting with the carboxy group of said compound of general formula IV to form a group with which a compound of general formula R<1>R<2>NH may react; subsequently reacting the resulting compound with a compound of general formula R<1>R<2>NH to form a compound of general formula III wherein X represents a cyano group; and optionally derivatising that compound to form other compounds of general formula III, is disclosed.</p> |
