| 发明名称 |
Cyclic renin inhibitors. |
| 摘要 |
<p>Compounds of the formula: <CHEM> are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.</p> |
| 申请公布号 |
EP0518676(A2) |
申请公布日期 |
1992.12.16 |
| 申请号 |
EP19920305384 |
申请日期 |
1992.06.11 |
| 申请人 |
MERCK & CO. INC. |
发明人 |
GREENLEE, WILLIAM J.;WEBER, ANN E.;RIVERO, RALPH A.;YANG, LIHU |
| 分类号 |
A61K31/335;A61K31/357;A61K31/395;A61K31/40;A61K31/41;A61K31/435;A61K31/445;A61K31/535;A61K38/00;A61P5/38;A61P9/00;A61P9/12;A61P27/02;A61P31/12;A61P43/00;C07D243/00;C07D245/02;C07D267/00;C07D281/00;C07D321/00;C07D327/02;C07D401/12;C07D403/12;C07D405/12;C07D413/12;C07D417/12;C07D453/02;C07D487/04;C07F9/655;C07F9/6558;C07F9/6561;C07K5/02;C07K5/06;C07K5/065;C07K5/078;C07K14/81 |
主分类号 |
A61K31/335 |
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