PROTEINS WITH FACTOR VIII ACTIVITY: PROCESS FOR THEIR PREPARATION USING GENETICALLY-ENGINEERED CELLS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Novel polypeptides having Factor VIII activity are provided as well as compositions and methods for their preparation. The polypeptides comprise derivatives and fragments of Factor VIII and have sequences substantially similar to portions of naturally occuring Factor VIII. The polypeptides find use in treatment of Hemophilia A.