发明名称 |
Substituted phenserines as specific inhibitors of acetylcholinesterase |
摘要 |
The present invention relates to substituted phenylcarbamate or naphthylcarbamate tricyclic compounds which provide highly potent and selective cholinergic agonist and blocking activity and their use as pharmaceutical agents. The invention further relates to improvements in therapy relative to cholinergic diseases such as glacuoma, Myasthenia Gravis, Alzheimer's disease and to improvements in therapy and organophosphate poisoning. The invention further provides for a selective acetylcholinesterase and butyrylcholinesterase agents and a method for inhibiting these esterases.
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申请公布号 |
US5171750(A) |
申请公布日期 |
1992.12.15 |
申请号 |
US19910765746 |
申请日期 |
1991.09.26 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
BROSSI, ARNOLD;BRZOSTOWSKA, MALGARZOTA;RAPOPORT, STANLEY I.;GREIG, NIGEL;HE, XIAO-SHU |
分类号 |
C07D487/04;C07D491/04;C07D491/048 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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