| 摘要 |
HALOACETAL COMPOUND A haloacetal compound obtained in a process for the preparation of 2-(10,11-dihydro-10-oxodibenzo¢b,f!thiepin-2-yl)propionic acid which shows high anti-inflammatory and analgetic action is disclosed. The process starts from a propiophenone derivative having the formula (II): (II) wherein R1 is hydrogen or a lower alkyl group, which is once converted into the haloacetal compound via a haloketone compound, and then converted into the desired dibenzothiepin derivative through a combination of rearrangement, hydrolysis and ring closure in variable sequence. |
