| 摘要 |
A process for the solid phase synthesis of peptides containing an aza-amino acid, for example the decapeptide goserelin, which comprises (i) assembling all the amino acids of the peptide except the C-terminal aza-amino acid by conventional solid phase synthesis; (ii) cleaving the peptide from the support with hydrazine or a substituted hydrazine; and (iii) reacting the hydrazide thus released with a cyanate ion.
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