| 摘要 |
<p>PURPOSE:To obtain the subject peptides having an allergy blocking effect with industrial advantage by condensing a tripeptide, L-aspartyl-L-prolyl-L-arginine with an amino group-protected L-aspartyl-L-serine and subsequently eliminating the protecting groups. CONSTITUTION:An amino-protected type tripeptide (e.g. N-t-butoxycarbonyl-beta- benzyl-L-aspartyl-L-prolyl-L-arginine) represented by formula I (R<1> is carboxyl- protecting group; R<4> is amino-protecting group) is, after removal of the amino- protecting group from the aspartic acid part thereof, subjected to fragment condensation with an amino-protected type dipeptide (e.g. N-t-butoxycarbonyl-beta- benzyl-L-aspartyl-L-serine) shown by formula II (R<2> is amino-protecting group; R<3> is carboxyl-protecting group) to obtain a pentapeptide represented by formula III. The protecting groups are then eliminated, thus obtaining the objective L-aspartyl-L-serylL-aspartyl-L-prolyl-L-arginine represented by formula IV.</p> |
