| 摘要 |
<p>PURPOSE:To obtain the subject peptides having an allergy blocking effect with industrial advantage by condensing L-aspartyl-L-prolyl-L-arginine in which the side chains are protected with an amino-protected L-aspartyl-L-serine and subsequently eliminating the protecting groups. CONSTITUTION:A tripeptide (e.g. N-t-butoxycarbonyl-(beta benzyl-L-aspartyl-L- prolyl-NG-nitro-L-arginine benzyl ester) represented by formula I (R<1> and R<3> are carboxylic group-protecting group; R<2> is guanidino group-protecting group; R<6> is amino-protecting group) is, after removal of the amino-protecting groups from the aspartic acid part thereof, subjected to fragment condensation with an amino-protected type dipeptide (e.g. N-t-butoxycarbonyl-beta-benzyl-L-aspartyl-L- serine) of formula II (R<4> is amino-protecting group; R<5> is carboxyl-protecting group) to obtain a pentapeptide of formula III. The protecting groups are subsequently eliminated, thus obtaining the objective L-aspartyl-L-serin-L-aspartyl-L- prolyl-L-arginine) of formula IV.</p> |
