| 摘要 |
<p>There is provided the use of a nucleotide analog of formula (I) wherein R1 represents (i) a hydrogen atom, (ii) a 2' or 3'-P-thionucleotidyl residue conjugated at its 5' position with an acyl group, (iii) a phosphoryl group, a P-thiophosphoryl group, a PO2R2H group optionally esterified with a linear or branched, cyclic or acyclic aliphatic hydroxy alkyl group having from 1 to 6 carbon atoms or with a lipophilic moiety or (iv) an acyl group; R2 represents a C¿1?-C6 alkyl group or hydrogen atom, and the pharmaceutically acceptable salts thereof, in the manufacture of a medicament for use as an antiviral, antitumour, immunomodulatory, interferon-enhancing or interferon-inducing agent. Some compounds of formula (I) are new. A process for their preparation and pharmaceutical compositions comprising them are also provided.</p> |
