| 摘要 |
<p>PURPOSE:To advantageously obtain anthranillic acids useful as raw materials for medicines, agricultural chemicals and dyes, etc., in one stage reaction, high purity and yield under suppression of side reactions at a low cost, in such reaction rate as to complete the reaction even in milder conditions than conventional conditions for several hours. CONSTITUTION:A compound expressed by formula I (X is Cl, Br or I; Y is H, halogen, lower alkyl, OH, alkoxy, acetoxy, NO2, NH2, sulfo, COOH, CF3 or aryl; (n) is integer of 1-4; M is H, ammonium, alkali metal or alkaline earth metal) is subjected to ammonolysis reaction in the presence of a copper (I)- containing catalyst [oxide preferably in oxidation state of copper (I), chloride, bromide, iodide, thiocyanate or cyanate of copper] of 0.001-1 gram atom in terms of copper atom based on 1mol of the compound of formula I to provide the objective compound expressed by formula II. After completion of the reaction, the reactional mixture is treated with a dithionite and/or hydrazine compound. Thereby the metal copper is deposited from the reactional mixture to efficiently separate from the objective compound.</p> |
