INDUCTION OF IMMUNE RESPONSE AGAINST TETANUS TOXIN THROUGH ADMINISTRATION OF MYCOBACTERIA EXPRESSING TETANUS TOXIN OR FRAGMENTS

摘要

2110687 9221374 PCTABS00017 A method of inducing an immune response to a tetanus toxin in an animal which comprises administering to the animal mycobacteria transformed with at least one DNA sequence which encodes a protein or polypeptide which elicits antibodies against tetanus toxin or a fragment or derivative thereof. In one embodiment, the immune response to tetanus toxin is induced by administering to an animal a vaccine including BCG which have been transformed with an expression vector DNA sequence which encodes Fragment C of tetanus toxin.