发明名称 |
[(Arylalkylpiperidine-4-yl)methyl]-2-alpha,3,4,5-tetrahydro-1(2H)-acenaphthylene-1-ones and related compounds, a process for their preparation and their use as medicaments. |
摘要 |
<p>There are disclosed various compounds of the formula below <CHEM> where X is hydrogen, loweralkyl, loweralkoxy, hydroxy or nitro; Y is hydrogen or loweralkoxy; or alternatively, X ans Y combined together form the group -OCH2O- in which case the positions of X and Y on the benzene ring moiety must be adjacent to each other; Z is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen or nitro and n is 0 or 1, which compounds are useful for alleviating various memory dysfunction characterizied by a cholinergic deficit such as Alzheimer's disease.</p> |
申请公布号 |
EP0517221(A1) |
申请公布日期 |
1992.12.09 |
申请号 |
EP19920109467 |
申请日期 |
1992.06.04 |
申请人 |
HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED |
发明人 |
KOSLEY, RAYMOND W. JR.;SPAHL, BETTINA |
分类号 |
A61K31/445;A61K31/00;A61K31/435;A61K31/443;A61K31/451;A61P25/28;C07D211/14;C07D211/22;C07D211/28;C07D211/30;C07D211/32;C07D211/38;C07D405/06 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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