发明名称 |
Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
摘要 |
Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC-target cell interaction are disclosed. Methods for using the claimed CLCs to obtain enhanced in vivo cytotoxicity and enhanced in vivo imaging are also described.
|
申请公布号 |
US5169933(A) |
申请公布日期 |
1992.12.08 |
申请号 |
US19890390241 |
申请日期 |
1989.08.07 |
申请人 |
NEORX CORPORATION |
发明人 |
ANDERSON, DAVID C.;MORGAN, JR., A. CHARLES;ABRAMS, PAUL G.;FRITZBERG, ALAN R.;NICHOLS, EVERETT J. |
分类号 |
A61K47/48;A61K51/10;C07K14/415;C12N15/62 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|