New tri:cyclic isoindole derivs.

摘要

Tricyclic isoindole derivs. of formula (I), and their tautomers, and salts are new. Where X = O, S, NH or N-(1-5C)alkylimino; Y = S, NH, SO, SO2, 1-5C alkylamino or 1-5C alkylcarbonylamino (sic); R = (a) H, 1-9C aliphatic gp. (opt. substd. by phenyl) R'OA or R'SA; (b) mono-, bi- or tricyclic carbocyclic ring contg. 7-15C or a heterocyclic mono-, bi- or tricyclic system contg. 5-6 atoms including 1-4 or 1-5 O, S or N atoms, respectively, in each ring. (C) Phenyl opt. substd. by one or more R', R'O, R'S, R'SO, R'SO2, Q, QO, QS, NH2, R'NH, (R)2n, R'CONH, R'NHCO, NH2CO, R'OCO, OH, PhCH2O, PhS, PhO, NO2, CN, halo, CF3, N2, HCONH, COOH OR Ph; R1, R2 = H, 1-6C aliphatic gp., R'O, R'S, R'SO, R'SO2, NH2, R'NH, (R')2NH, sulphonamido, R'OCO, COOH, halo, OH, NO2, CN, N3, Ph or PhCH2O; R3,R4 = H, R', R'O, R'S, NH2, R'NH,(R')2NH, halo, CN, OH, COOH or R'OCO; R' = 1-6C alkyl; A = 1-6C alkylene; Q = 2-6C alkynyl or 2-6C alkenyl; Ph = phenyl.