摘要 |
Compounds of formula (I) and pharmaceutically acceptable salts thereof: (I) wherein R1 and R2 are independently hydrogen or C1-6 alkyl; Z is a group of sub-formula (a), (b), (c), (d) or (e): (a) (b) (c) (d) wherein xa to xd are selected from hydrogen, halogen and hydroxy; R3 is hydrogen and R4 is hydrogen or C1-6 alkyl, or R3 and R4 together are a bond; R5 to R10 are independently selected from hydrogen or C1-6 alkyl; and R6 together with R4 may be C2-7 polymethylene when R3 is hydrogen, or R9 and R10 may together be C2-7 polymethylene; having 5-HT3 receptor antagonist activity, processes for their preparation and their use as pharmaceuticals. |