HYPERTONIC ISOCHLOREMIC FORMULATION FOR CIRCULATORY SHOCK

摘要

2103246 9221356 PCTABS00017 The present invention relates to a hypertonic crystalloid resuscitation fluid particularly useful in treating circulatory shock arising from loss of blood. A pharmaceutical formulation prepared from sodium chloride in a range of about 2-7 osmolar parts and sodium acetate in a range of about 1-2 osmolar parts where the total osmolar concentration exceeds 500 mOsm can be used as a small volume rapid bolus resuscitation fluid which has little effect on plasmachloride levels. Blood flow is improved while arterial pressure is improved to the point of sustaining oxygen supply to tissues and organs in the recumbent recipient.