| 摘要 |
New substituted urea compounds of formula I, or a pharmaceutically acceptable salt thereof: <CHEM> wherein R<1> is a group of formula II, III or IV <CHEM> where n is 2 or 3, p is 1 or 2, q is 1 to 3, r is 1-3 and R<4> and R<5> are H,C1-7 alkyl or C3-6 cycloalkyl; and wherein R<2> is an oxadiazole, substituted with C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-7 cycloalkyl, benzyl, phenyl, C1-6 alkoxy, C1-6 alkylthio, amino or alkylamino; or wherein R<2> is -C-R<6>=N-O-R<7> wherein R<6> is hydrogen or methyl and R<7> is C1-6 alkyl which may be substituted with C3-7 cycloalkyl; and wherein R<3> is hydrogen, halogen, nitro, substituted amine, trifluoromethyl, C1-6 alkyl or C1-6 alkoxy. The compounds are useful in pharmaceutical preparations for treating psychotic disorders, nausea and vomiting. |
