| 发明名称 |
3'-END BLOCKED OLIGONUCLEOTIDES |
| 摘要 |
The invention provides oligonucleotides having 3'-ends blocked by cap structures and having one or more artificial internucleoside linkage. Such oligonucleotides are resistant to in vivo degradation and extension, and thus have superior half-life in vivo. |
| 申请公布号 |
WO9220697(A1) |
申请公布日期 |
1992.11.26 |
| 申请号 |
WO1992US03867 |
申请日期 |
1992.05.08 |
| 申请人 |
HYBRIDON, INC. |
发明人 |
AGRAWAL, SUDHIR;TEMSAMANI, JAMAL;TANG, JIN-YAN |
| 分类号 |
A61K31/70;A61K31/7088;A61K48/00;A61P31/12;C07H21/00 |
主分类号 |
A61K31/70 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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