| 摘要 |
PURPOSE: To obtain an angiogenesis inhibitor containing benzoyl carbinol or its ester, useful for treatment of chronic inflammation, diabetic retinopathy, psoriasis, chronic arthrorheumatism, hyperplasia of cancers or the like. CONSTITUTION: This inhibitor contains, as the active ingredient, a compound shown by formula I R is H or shown by formula II [R1 is a 1-6C alkyl or shown by formula III (R2 and R3 are each H, a 1-6C alkyl or 5-6C cycloalkyl, or forms a monoheterocyclic structure together with a chemically bound N atom)]} or a medically permissible salt thereof, e.g. benzoyl carbinol trimethylacetate. The above salt can be formed by the reaction with an inorganic acid, e.g. hydrochloric, sulfuric or phosphoric acid or the like, or an organic acid, e.g. tartaric, citric or methanesulfonic acid or the like, to improve solubility of the compound in water, making the inhibitor more adaptable, e.g. to intramuscular injection. |
