Benzazepin derivatives as vasopressin antagonists.

摘要

Novel benzoheterocyclic compounds of the formula: <CHEM> wherein R<1> is H, halogen, OH, etc,; R<2> is H, alkyl, halogen or alkoxy; R<3> is phenyl-alkanoylamino, or <CHEM> R<4> is H, -NR<6>R<7>, alkenyloxy, HO-alkyl, -O-CO-A-NR<8>R<9>, etc.; R<5> is H, OH, etc., or a salt thereof, which have excellent vasopressin antagonistic activities and useful as vasodilator, hypotensive agent, water diuretics, platelet agglutination inhibitor, and a vasopressin antagonistic composition containing the compound as the active ingredient.