METHOD OF CRYSTALLIZING .ALPHA.-L-ASPARTYL-L-PHENYLALANINE METHYL ESTER

摘要

In crystallizing .alpha.-APM from its aqueous solvent in a crystallizer, the pressure in the crystallizer is held at not higher than atmospheric pressure, a water or water/alcohol mixed solution of .alpha.-APM is fed into the crystallizer with stirring so that the solvent is vaporized, and the crystallizing solution is cooled and crystallized by the latent heat of vaporization or is heated so as to prevent supercooling.