发明名称 |
Carrier system and method for the introduction of genes into mammalian cells |
摘要 |
A targetable gene delivery system is provided for introducing foreign genes into mammalian cells. The system employs a soluble targetable DNA complex and utilizes receptor-mediated endocytosis to endow cell specificity. The soluble DNA-carrying complex is formed by non-covalently binding a ligand conjugate with the foreign gene. The conjugate, in turn, is formed by bonding receptor-specific ligands such as asialoglycoproteins to polycations such as polylysine through covalent bonds such as disulfide bonds. The system exhibits a high degree of cell specificity and offers potential for the treatment of inherited genetic disorders.
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申请公布号 |
US5166320(A) |
申请公布日期 |
1992.11.24 |
申请号 |
US19900504064 |
申请日期 |
1990.04.02 |
申请人 |
UNIVERSITY OF CONNECTICUT |
发明人 |
WU, GEORGE Y.;WU, CATHERINE H. |
分类号 |
A61K47/48;C12N15/87 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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地址 |
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