Cecropin polypetides with activity against Gram-positive and Gram-negative bacteria

摘要

The invention relates to cecropin-like polypeptides with a variey of C-terminus modifications. Conversion of the terminal carboxy group to a homoserine extended neutral, negatively charged or positively charged form results in the polypeptides of the invention that have significant bactericidal effects against both Gram-positive and Gram-negative bacteria.