发明名称 IMIDAZO-BENZODIAZEPINES AND THEIR USE IN THE TREATMENT OF MEMORY OR CEREBRAL SENESCENCE DISORDERS
摘要 Disclosed are compounds of formula (I): (I) wherein R1 represents a phenyl group, a C4-C6 cycloalkyl group or a group of formula (II): (II) (in which R4 represents hydrogen or C1-C5 alkyl: R5 represents hydrogen or C1-C5 alkyl; and R6 represents hydrogen, C1-C5 alkyl, phenyl, halogen, C2-C5 alkoxycarbonyl, cyano, amido or C1-C5 mono- or dialkylamido), R2 and R3, which may be identical or different, each represents a hydrogen atom, a C1-C5 alkyl group or a C2-C5 cycloalkyl group, or R2 and R3 together represent a C3-C5 alkylene group; and X and Y, which may be identical or different, each represents a hydrogen atom, a halogen atom, a nitro,azido, nitrile or trifluoromethyl group or an alkyl or alkoxy group containing 1 to 3 carbon atoms. These compounds and their acid addition salts are useful as medicaments, particularly in the treatment of memory disorders or cerebral senescence disorders. Some compounds may also be used in the treatment of obesity and as minor tranquillisers in the treatment of certain agitated or irritated conditions, and certain forms of epilepsy.
申请公布号 CA1310638(C) 申请公布日期 1992.11.24
申请号 CA19880575843 申请日期 1988.08.26
申请人 ROUSSEL-UCLAF 发明人 GARDNER, COLIN R.;HEDGECOCK, CHARLES J. R.
分类号 A61K31/55;A61K31/5517;A61P3/04;A61P25/08;A61P25/20;A61P25/22;A61P25/28;C07D487/04 主分类号 A61K31/55
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