INTERMEDIATE FOR SYNTHESIS OF CARBAPENEM AND PRODUCTION OF SAID INTERMEDIATE.

摘要

A carbapenem derivative having an R-configuration at the 5-position, represented by general formula (I), and optically active pyrrolidine derivatives represented by general formulae (XI) and (XII), all of these compounds serving as the intermediate for the synthesis of carbapenems as beta -lactam antibiotics. In formula (I) R<1> represents hydrogen or an organic group; and R<2> represents hydrogen or a carboxyl protective group. In formulae (XI) and (XII) R<1> represents benzyl; R<2> represents alkyl; R<3> represents alkyl, benzyl or allyl; R<4> represents hydrogen, alkyl, vinyl, phenyl, benzyl or a heterocyclic group containing 1 to 4 nitrogen or/and oxygen atoms; and R<5> represents hydrogen or methyl.