N-alkyltauroursodeoxycholic acids and their therapeutically active derivatives, a process for their preparation and pharmaceutical compositions containing them.

摘要

The N-alkyl-tauroursodeoxycholic acids of formula (I) and their pharmaceutically acceptable derivatives are useful in the therapy of hepatic diseases and troubles. For the preparation of these acids a conjugation reaction is effected between a mixed anhydride of ursodeoxycholic acid and alkyltaurine, the acide being then obtained by percolation through two columns respectively containing a strong cationic resin in H<+> form and a weakly anionic resin in OH<-> form. <CHEM> r