| 摘要 |
The present invention relates to an anti-idiotypic monoclonal antibody raised against a mouse monoclonal antibody or fragments thereof specific to at least one diarrhetic shellfish poisoning toxin selected from the group consisting of okadaic acid and derivatives thereof. The anti-idiotypic antibody is characterized by reacting only with antibodies to okadaic acid and derivatives thereof but not with antibodies directed against any other compounds. The anti-idiotypic antibody is further characterized by being an internal image of okadaic acid and derivatives thereof. A hybridoma producing an anti-idiotypic antibody in accordance with the present invention has been deposited at the ATCC under accession number HB 10768. Competitive solid-phase assays for determining the amount of okadaic acid and derivatives thereof in marine samples are also provided in accordance with the present invention. The present invention also relates to a kit for determining the amount of okadaic acid and derivatives thereof in marine samples. |
