Preparation of thionucleosides.

摘要

The invention relates to the preparation of homochiral thiolactones which have application in the synthesis of 3 min - and 4 min - thionucleosides. Substituents on the thiolactone can be used to influence the configuration of the C-1 min position in the final nucleoside. Configuration at the C-4 min position is controlled by use of the appropriate homochiral glycidol as starting material in the synthesis of the thiolactone. This process also offers the possibility of introducing substituents diastereoselectively in the C-2 min and C-3 min positions.