AMINO ACID AZETIDINYL SUBSTITUTED PYRIDONE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICATIONS

摘要

Compounds corresponding to the general formula I and their pharmaceutically acceptable salts, in which formula X represents a nitrogen atom or else a carbon atom bonded to a hydrogen atom, a halogen atom, a hydroxyl or alkyloxy radical, an alkyl radical, a halogenated alkyl radical or an alkylamino radical; R1 represents a lower alkyl or cycloalkyl radical, a lower haloalkyl radical, a hydroxyalkyl radical, a vinyl radical, an aryl radical or an aryl radical substituted by one or more fluorine atoms, or an alkylamino radical; R2 represents a hydrogen atom or a lower alkyl radical; R3 represents a hydroxyl radical or a lower C1 to C4 alkyloxy radical; R4 represents a hydrogen atom, a fluorine atom, a lower alkyl radical, a nitro radical, an amino radical or a substituted amino radical; R5, R6 and R7 represent a hydrogen atom or a lower alkyl radical; n is a number which can be 0 or 1; X and R1 can together form a bond represented by a group C-CH2-CH2-CH-R9 or C-O-CH-CH2-CH-R9 or C-S-CH2-CH-R9 in which R9 represents a hydrogen atom, a lower alkyl radical or a lower haloalkyl radical; R1 and R2 can together form a bond represented by a group -CHR10-S- in which R10 represents a hydrogen atom or a lower alkyl radical or a lower haloalkyl radical; R2 and R3 can together form a bond represented by an -S-NH- group; A is a solubilising group which is represented by a residual amino acid or a polypeptide chain consisting of two to four or more amino acid residues, which are bonded covalently to each other by peptide bonds, and process for their preparation.r