| 摘要 |
<p>Synthetic peptides of formula (I) and their nontoxic salts are new. R1-R2-R3-Ala- Ile-Phe-Thr-R8- Ser-R10-Arg-R12-R13-Leu-R13-Gln- R17-R18-Ala-Arg- Lys-Leu-R23-R24- R25-Ile-R27-R28-Arg-Gln-Gln-Gly- Glu-R34-Asn-Gln- Glu-R38-R39-R40-Arg-R42-R43-R44 (I) In (I), R1=Tyr, D-Tyr, Met,Phe, D-Phe, 4-chloro-Phe, Leu, His or D-His, and is opt. C alpha- or Nalpha-CH3 substd. R2 = Ala or D-Ala; R3 = Asp or D-Asp; R8 = Ser, Asn, D-Ser or D-Asn; R10= Tyr or D-Tyr; R12 = Arg or Lys; R13= Ile or Val, R15 = Gly or D-Ala; R17 = Leu or D-Leu; R18 = Tyr or Ser; R23 = Leu or D-Geu; R24 = His or Gln; R25 = Glu, Asp, D-Gln or D-Asp; R27 = Met, D-Met, Ala, Nla, Ile, Leu, Nva or Val; R28 = Asn or Ser; R34 = Arg or Ser; R38 = Gln or Arg; R39 = Arg or Gly; R40 = Ser or Ala; R42 = Phe, Ala or Val; R43 = Asn or Arg; R44 = natural amino, and any or all of residues R29 to R44 can be deleted. Proviso are of the following conditions must apply: (I) R1 is alpha-CH3 substd; (2) R17 and/or R23 is D-Leu; (3) R25 is D-Glu or D-Asp.</p> |
