| 摘要 |
It has been discovered that 6-(substituted amino)purine cytokinins, such as kinetin, induce differentiation, and consequent- ly reduce or eliminate the abnormally high rate of proliferation, of hyperproliferating cells associated with hyperproliferative skin diseases, such as psoriasis. Thus, the present invention provides methods an d compositions for treating hyperproliferative skin diseases in mammals, particularly such diseases associated with hyperproliferating epidermal cells in humans, by administering to the hyperproliferating cells associated with such a disease, in the skin of a mammal suffering therefrom, a differentiation-indu- cing effective amount of a 6-(substituted amino)purine cytokinin.
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