| 摘要 |
PURPOSE:To obtain a sustained release medicine-containing ceramic porous substance capable of sustaining a medicine for a long period and preventing side effects due to concentrated elution of the medicine by applying a biodegradable substrate containing the medicine, dispersed and held therein to the inner wall surfaces in pores and the outside surface of a ceramic porous substance. CONSTITUTION:A sustained release medicine-containing ceramic porous substance is obtained by applying a biodegradable substrate containing and holding a dispersed medicine therein and further containing at least one selected from chitin and its derivative or collagen to the inner wall surfaces of pores and the outside surface of a ceramic porous substance composed of calcium phosphate-based ceramics, alumina, zirconia, etc. Calcium phosphate-based ceramics excellent in biocompatibility, etc., are preferred as the aforementioned ceramics and tricalcium phosphate and hydroxyapatite at 1.4-1.7 atomic ratio (Ca/P) are especially preferred in aspect of rapid production of newly formed bones. The porosity of the ceramic porous substance is preferably 30-95% and the average pore diameter is preferably within the range of 10-300mum. |
