| 摘要 |
6-(substituted amino)purine cytokinins, including kinetin, have been discovered to ameliorate the adverse effects of aging on mammalian cells, by slowing or reversing the morphological changes that normally accompany aging of such cells, without significantly increasing the growth rate or total proliferative capacity of such cells. Thus, method are provided for countering the adverse effects of aging on cells in culture and in vivo which comprise administering to said cells an adverse-age-effect-ameliora- tive amount of kinetin or, another 6-(substituted amino)purine cytokinin. Compositions for carrying out the methods are also pro- vided. Among the preferred applications of the invention are the preservatio n of the health of mammalian cells in culture and, by application to human skin of kinetin-containing lotions, ointments or creams , the health and youthful appearance of skin.
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